Metabolic clearance of select opioids and opioid antagonists using hepatic spheroids and recombinant cytochrome P450 enzymes

• Main Authors: Wing Y. Tuet (Author), Samuel A. Pierce (Author), Matthieu Conroy (Author), Justin N. Vignola (Author), Justin Tressler (Author), Robert C. diTargiani (Author), Bryan J. McCranor (Author), Benjamin Wong (Author)
• Format: Book
• Published: Wiley, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The opioid crisis is a pressing public health issue, exacerbated by the emergence of more potent synthetic opioids, particularly fentanyl and its analogs. While competitive antagonists exist, their efficacy against synthetic opioids is largely unknown. Furthermore, due to the short duration...