Sequence-structure functional implications and molecular simulation of high deleterious nonsynonymous substitutions in IDH1 revealed the mechanism of drug resistance in glioma

• Autores principales: Muhammad Suleman (Autor), Syeda Umme- (Autor), Muhammad Salman (Autor), Mohammed Aljuaid (Autor), Abbas Khan (Autor), Arshad Iqbal (Autor), Zahid Hussain (Autor), Syed Shujait Ali (Autor), Liaqat Ali (Autor), Hassan Sher (Autor), Yasir Waheed (Autor), Dong-Qing Wei (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

In the past few years, various somatic point mutations of isocitrate dehydrogenase (IDH) encoding genes (IDH1 and IDH2) have been identified in a broad range of cancers, including glioma. Despite the important function of IDH1 in tumorigenesis and its very polymorphic nature, it is not yet clear how...