Sequence-structure functional implications and molecular simulation of high deleterious nonsynonymous substitutions in IDH1 revealed the mechanism of drug resistance in glioma

• Main Authors: Muhammad Suleman (Author), Syeda Umme- (Author), Muhammad Salman (Author), Mohammed Aljuaid (Author), Abbas Khan (Author), Arshad Iqbal (Author), Zahid Hussain (Author), Syed Shujait Ali (Author), Liaqat Ali (Author), Hassan Sher (Author), Yasir Waheed (Author), Dong-Qing Wei (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the past few years, various somatic point mutations of isocitrate dehydrogenase (IDH) encoding genes (IDH1 and IDH2) have been identified in a broad range of cancers, including glioma. Despite the important function of IDH1 in tumorigenesis and its very polymorphic nature, it is not yet clear how...