Nelfinavir, an HIV-1 protease inhibitor, induces oxidative stress-mediated, caspase-independent apoptosis in Leishmania amastigotes.

• Main Authors: Pranav Kumar (Author), Robert Lodge (Author), Nathalie Trudel (Author), Michel Ouellet (Author), Marc Ouellette (Author), Michel J Tremblay (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Visceral leishmaniasis has now emerged as an important opportunistic disease in patients coinfected with human immunodeficiency virus type-1 (HIV-1). Although the effectiveness of HIV-1 protease inhibitors, such as nelfinavir, in antiretroviral therapies is well documented, little is known of the im...