Cytosolic Double-Stranded DNA as a Damage-Associated Molecular Pattern Induces the Inflammatory Response in Rat Pancreatic Stellate Cells: A Plausible Mechanism for Tissue Injury-Associated Pancreatitis

• Main Authors: Taichi Nakamura (Author), Tetsuhide Ito (Author), Hisato Igarashi (Author), Masahiko Uchida (Author), Masayuki Hijioka (Author), Takamasa Oono (Author), Nao Fujimori (Author), Yusuke Niina (Author), Koichi Suzuki (Author), Robert T. Jensen (Author), Ryoichi Takayanagi (Author)
• Format: Book
• Published: Hindawi Limited, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatitis is an inflammatory disease of unknown causes. There are many triggers causing pancreatitis, such as alcohol, common bile duct stone, virus and congenital or acquired stenosis of main pancreatic duct, which often involve tissue injuries. Pancreatitis often occurs in sterile condition, wh...