Inter- and intra-host sequence diversity reveal the emergence of viral variants during an overwintering epidemic caused by dengue virus serotype 2 in southern Taiwan.

• Main Authors: Hui-Ying Ko (Author), Yao-Tsun Li (Author), Day-Yu Chao (Author), Yun-Cheng Chang (Author), Zheng-Rong T Li (Author), Melody Wang (Author), Chuan-Liang Kao (Author), Tzai-Hung Wen (Author), Pei-Yun Shu (Author), Gwong-Jen J Chang (Author), Chwan-Chuen King (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purifying selection during dengue viral infection has been suggested as the driving force of viral evolution and the higher complexity of the intra-host quasi-species is thought to offer an adaptive advantage for arboviruses as they cycle between arthropod and vertebrate hosts. However, very few stu...