Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research: In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome: Development of Chronic Atrioventricular Block Model of Microminipig

• Main Authors: Atsushi Sugiyama (Author), Yuji Nakamura (Author), Yasuki Akie (Author), Hiroyuki Saito (Author), Yasukatsu Izumi (Author), Hiroshi Yamazaki (Author), Naoki Kaneko (Author), Katzuhiko Itoh (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new in vivo proarrhythmia model of drug-induced long QT syndrome was developed using the Microminipig, an incredibly small minipig established by Fuji Micra Inc. (Shizuoka). The atrioventricular (AV) node of the Microminipig of either sex weighing approximately 6 - 7 kg was ablated under halothane...