Derivatives of Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Hepatic Stage of <i>Plasmodium berghei</i> Infection In Vitro

• Main Authors: Kateřina Hradiská Breiterová (Author), Aneta Ritomská (Author), Diana Fontinha (Author), Jana Křoustková (Author), Daniela Suchánková (Author), Anna Hošťálková (Author), Marcela Šafratová (Author), Eliška Kohelová (Author), Rozálie Peřinová (Author), Rudolf Vrabec (Author), Denise Francisco (Author), Miguel Prudêncio (Author), Lucie Cahlíková (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The incidence rate of malaria and the ensuing mortality prompts the development of novel antimalarial drugs. In this work, the activity of twenty-eight Amaryllidaceae alkaloids (<b>1-28</b>) belonging to seven different structural types was assessed, as well as twenty semisynthetic deriv...