Preclinical Characterization of Antioxidant Quinolyl Nitrone QN23 as a New Candidate for the Treatment of Ischemic Stroke

• Main Authors: Emma Martínez-Alonso (Author), Alejandro Escobar-Peso (Author), Alicia Aliena-Valero (Author), Germán Torregrosa (Author), Mourad Chioua (Author), Rocío Fernández-Serra (Author), Daniel González-Nieto (Author), Youness Ouahid (Author), Juan B. Salom (Author), Jaime Masjuan (Author), José Marco-Contelles (Author), Alberto Alcázar (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nitrones are encouraging drug candidates for the treatment of oxidative stress-driven diseases such as acute ischemic stroke (AIS). In a previous study, we found a promising quinolylnitrone, QN23, which exerted a neuroprotective effect in neuronal cell cultures subjected to oxygen-glucose deprivatio...