Metformin Attenuates Silica-Induced Pulmonary Fibrosis by Activating Autophagy via the AMPK-mTOR Signaling Pathway

• Main Authors: Shu-xian Li (Author), Chao Li (Author), Xin-ru Pang (Author), Juan Zhang (Author), Gong-chang Yu (Author), Abrey J. Yeo (Author), Martin F. Lavin (Author), Hua Shao (Author), Qiang Jia (Author), Cheng Peng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Long-term exposure to crystalline silica particles leads to silicosis characterized by persistent inflammation and progressive fibrosis in the lung. So far, there is no specific treatment to cure the disease other than supportive care. In this study, we examined the effects of metformin, a prescribe...