Circulating cell-free DNA (cfDNA) in patients with medullary thyroid carcinoma is characterized by specific fragmentation and methylation changes with diagnostic value

• Main Authors: Anna Citarella (Author), Zein Mersini Besharat (Author), Sofia Trocchianesi (Author), Tanja Milena Autilio (Author), Antonella Verrienti (Author), Giuseppina Catanzaro (Author), Elena Splendiani (Author), Zaira Spinello (Author), Silvia Cantara (Author), Patrizia Zavattari (Author), Eleonora Loi (Author), Cristina Romei (Author), Raffaele Ciampi (Author), Luciano Pezzullo (Author), Maria Grazia Castagna (Author), Antonio Angeloni (Author), Rosella Elisei (Author), Cosimo Durante (Author), Agnese Po (Author), Elisabetta Ferretti (Author)
• Format: Book
• Published: BMC, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Medullary Thyroid Carcinoma (MTC) is a rare neuroendocrine tumour whose diagnosis includes evaluating calcitonin serum levels, which can present fluctuations unrelated to MTC. Here, we investigated circulating DNA fragmentation and methylation changes as potential biomarkers using ddPCR on...