L-arginine availability and arginase activity: Characterization of amino acid permease 3 in Leishmania amazonensis.

• Main Authors: Juliana Ide Aoki (Author), Sandra Marcia Muxel (Author), Ricardo Andrade Zampieri (Author), Stephanie Maia Acuña (Author), Juliane Cristina Ribeiro Fernandes (Author), Rubia Heloisa Vanderlinde (Author), Maria Carmen Oliveira de Pinho Sales (Author), Lucile Maria Floeter-Winter (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leishmania uses the amino acid L-arginine as a substrate for arginase, enzyme that produces urea and ornithine, last precursor of polyamine pathway. This pathway is used by the parasite to replicate and it is essential to establish the infection in the mammalian host. L-arginine is not synthesized b...