Seeking the exclusive binding region of phenylalkylamine derivatives on human T‐type calcium channels via homology modeling and molecular dynamics simulation approach

• Главные авторы: You Lu (Автор), Ming Li (Автор), Gi Young Lee (Автор), Na Zhao (Автор), Zhong Chen (Автор), Andrea Edwards (Автор), Kun Zhang (Автор)
• Формат: ‌
• Опубликовано: Wiley, 2021-05-01T00:00:00Z.
• Предметы: article
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Abstract Pharmaceutical features of phenylalkylamine derivatives (PAAs) binding to calcium channels have been studied extensively in the past decades. Only a few PAAs have the binding specificity on calcium channels, for example, NNC 55‐0396. Here, we created the homology models of human Cav3.2, Cav...