Decreased DNA methylation in the promoter region of the WNT5A and GDNF genes may promote the osteogenicity of mesenchymal stem cells from patients with ossified spinal ligaments

• Κύριοι συγγραφείς: Noriyuki Chiba (Συγγραφέας), Ken-Ichi Furukawa (Συγγραφέας), Shohei Takayama (Συγγραφέας), Toru Asari (Συγγραφέας), Shunfu Chin (Συγγραφέας), Yoshifumi Harada (Συγγραφέας), Gentaro Kumagai (Συγγραφέας), Kanichiro Wada (Συγγραφέας), Toshihiro Tanaka (Συγγραφέας), Atsushi Ono (Συγγραφέας), Shigeru Motomura (Συγγραφέας), Manabu Murakami (Συγγραφέας), Yasuyuki Ishibashi (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2015-04-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Mesenchymal stem cells (MSCs) isolated from spinal ligaments with ectopic ossification have a propensity toward the osteogenic lineage. To explore epigenetic control of the osteogenic features of MSCs, we treated MSCs obtained from the spinal ligaments of ossification of yellow ligament (OYL) patien...