Decreased DNA methylation in the promoter region of the WNT5A and GDNF genes may promote the osteogenicity of mesenchymal stem cells from patients with ossified spinal ligaments

• Main Authors: Noriyuki Chiba (Author), Ken-Ichi Furukawa (Author), Shohei Takayama (Author), Toru Asari (Author), Shunfu Chin (Author), Yoshifumi Harada (Author), Gentaro Kumagai (Author), Kanichiro Wada (Author), Toshihiro Tanaka (Author), Atsushi Ono (Author), Shigeru Motomura (Author), Manabu Murakami (Author), Yasuyuki Ishibashi (Author)
• Format: Book
• Published: Elsevier, 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mesenchymal stem cells (MSCs) isolated from spinal ligaments with ectopic ossification have a propensity toward the osteogenic lineage. To explore epigenetic control of the osteogenic features of MSCs, we treated MSCs obtained from the spinal ligaments of ossification of yellow ligament (OYL) patien...