Catalase Modulates the Radio-Sensitization of Pancreatic Cancer Cells by Pharmacological Ascorbate

• Main Authors: Juan Du (Author), Rory S. Carroll (Author), Garett J. Steers (Author), Brett A. Wagner (Author), Brianne R. O'Leary (Author), Chris S. Jensen (Author), Garry R. Buettner (Author), Joseph J. Cullen (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic cancer cells (PDACs) are more susceptible to an oxidative insult than normal cells, resulting in greater cytotoxicity upon exposure to agents that increase pro-oxidant levels. Pharmacological ascorbate (P-AscH⁻), i.e., large amounts given intravenously (IV), generat...