Catalase Modulates the Radio-Sensitization of Pancreatic Cancer Cells by Pharmacological Ascorbate

• मुख्य लेखकों: Juan Du (लेखक), Rory S. Carroll (लेखक), Garett J. Steers (लेखक), Brett A. Wagner (लेखक), Brianne R. O'Leary (लेखक), Chris S. Jensen (लेखक), Garry R. Buettner (लेखक), Joseph J. Cullen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2021-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Pancreatic cancer cells (PDACs) are more susceptible to an oxidative insult than normal cells, resulting in greater cytotoxicity upon exposure to agents that increase pro-oxidant levels. Pharmacological ascorbate (P-AscH⁻), i.e., large amounts given intravenously (IV), generat...