Activation of p53 signaling and regression of breast and prostate carcinoma cells by spirooxindole-benzimidazole small molecules

• Main Authors: Assem Barakat (Author), Saeed Alshahrani (Author), Abdullah Mohammed Al-Majid (Author), Abdullah Saleh Alamary (Author), Matti Haukka (Author), Marwa M. Abu-Serie (Author), Alexander Dömling (Author), Luis R. Domingo (Author), Yaseen A. M. M. Elshaier (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study discusses the synthesis and use of a new library of spirooxindole-benzimidazole compounds as inhibitors of the signal transducer and activator of p53, a protein involved in regulating cell growth and cancer prevention. The text includes the scientific details of the [3 + 2] cycloaddition...