Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms

• Main Authors: Wagdy M. Eldehna (Author), Mohammed S. Taghour (Author), Tarfah Al-Warhi (Author), Alessio Nocentini (Author), Mostafa M. Elbadawi (Author), Hazem A. Mahdy (Author), Mohamed A. Abdelrahman (Author), Ohoud J. Alotaibi (Author), Nada Aljaeed (Author), Diaaeldin M. Elimam (Author), Kamyar Afarinkia (Author), Hatem A. Abdel-Aziz (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Different 2,4-thiazolidinedione-tethered coumarins 5a-b, 10a-n and 11a-d were synthesised and evaluated for their inhibitory action against the cancer-associated hCAs IX and XII, as well as the physiologically dominant hCAs I and II to explore their selectivity. Un-substituted phenyl-bearing coumari...