Cover Image

Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms

Different 2,4-thiazolidinedione-tethered coumarins 5a-b, 10a-n and 11a-d were synthesised and evaluated for their inhibitory action against the cancer-associated hCAs IX and XII, as well as the physiologically dominant hCAs I and II to explore their selectivity. Un-substituted phenyl-bearing coumari...

Full description

Saved in:

Bibliographic Details
Main Authors:	Wagdy M. Eldehna (Author), Mohammed S. Taghour (Author), Tarfah Al-Warhi (Author), Alessio Nocentini (Author), Mostafa M. Elbadawi (Author), Hazem A. Mahdy (Author), Mohamed A. Abdelrahman (Author), Ohoud J. Alotaibi (Author), Nada Aljaeed (Author), Diaaeldin M. Elimam (Author), Kamyar Afarinkia (Author), Hatem A. Abdel-Aziz (Author), Claudiu T. Supuran (Author)
Format:	Book
Published:	Taylor & Francis Group, 2022-12-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII
by: Tarfah Al-Warhi, et al.
Published: (2022)

1,2,4-Triazole-Tethered Indolinones as New Cancer-Fighting Small Molecules Targeting VEGFR-2: Synthesis, Biological Evaluations and Molecular Docking
by: Ahmed E. Elsawi, et al.
Published: (2024)

Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights
by: Ahmed Sabt, et al.
Published: (2020)

Identification of Novel Cyanopyridones and Pyrido[2,3-<em>d</em>]Pyrimidines as Anticancer Agents with Dual VEGFR-2/HER-2 Inhibitory Action: Synthesis, Biological Evaluation and Molecular Docking Studies
by: Tarfah Al-Warhi, et al.
Published: (2022)

In vitro antimicrobial combat, molecular modelling and structure activity relationship studies of novel class of aryl-ethyne tethered coumarin analogues and some 3-aryl coumarin derivatives
by: Pavankumar Prabhala, et al.
Published: (2022)

Natural inspired piperine-based ureas and amides as novel antitumor agents towards breast cancer
by: Diaaeldin M. Elimam, et al.
Published: (2022)

Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity
by: Haytham O. Tawfik, et al.
Published: (2022)

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
by: Moataz A. Shaldam, et al.
Published: (2023)

Discovery of pyrimidine-tethered benzothiazole derivatives as novel anti-tubercular agents towards multi- and extensively drug resistant Mycobacterium tuberculosis
by: Loah R. Hemeda, et al.
Published: (2023)

GC-MS metabolites profiling of anethole-rich oils by different extraction techniques: antioxidant, cytotoxicity and in-silico enzymes inhibitory insights
by: Dina M. El-Kersh, et al.
Published: (2022)

Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies
by: Wagdy M. Eldehna, et al.
Published: (2021)

The End of the Tether
by: Conrad, Joseph, 1857-1924

Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies
by: Ahmed Sabt, et al.
Published: (2018)

Chemical composition, seasonal variation and antiaging activities of essential oil from Callistemon subulatus leaves growing in Egypt
by: Omyma Rabie, et al.
Published: (2023)

Challenges in drug discovery for thiazolidinedione substitute
by: Jian-ping Ye
Published: (2011)

Enaminone-based carboxylic acids as novel non-classical carbonic anhydrases inhibitors: design, synthesis and in vitro biological assessment
by: Mahmoud F. Abo-Ashour, et al.
Published: (2022)

Identification of sulphonamide-tethered N-((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease
by: Mai H. ElNaggar, et al.
Published: (2023)

Tethered Spinal Cords
by: J Gordon Millichap
Published: (1989)

Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamides as carbonic anhydrase isoforms I and II inhibitors
by: Mohammad M. Al-Sanea, et al.
Published: (2019)

Novel thiazolidinedione analog reduces a negative impact on bone and mesenchymal stem cell properties in obese mice compared to classical thiazolidinediones
by: Andrea Benova, et al.
Published: (2022)

Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents
by: Wagdy M. Eldehna, et al.
Published: (2019)

Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights
by: Wagdy M. Eldehna, et al.
Published: (2022)

New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies
by: Eslam B. Elkaeed, et al.
Published: (2022)

Novel [(N-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and in silico studies
by: Tarfah Al-Warhi, et al.
Published: (2020)

Coumarins effectively inhibit bacterial α-carbonic anhydrases
by: Simone Giovannuzzi, et al.
Published: (2022)

Vertebral body tethering: An alternative to posterior spinal fusion in idiopathic scoliosis?
by: Ahmad M. Hammad, et al.
Published: (2023)

The metabolic syndrome, thiazolidinediones, and implications for intersection of chronic and inflammatory disease
by: Jerry R. Colca, et al.
Published: (2022)

Coumarins inhibit η-class carbonic anhydrase from Plasmodium falciparum
by: Simone Giovannuzzi, et al.
Published: (2022)

Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFRWT and EGFRT790M inhibitors
by: Tarfah Al-Warhi, et al.
Published: (2023)

Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators
by: Mohammed Farrag El-Behairy, et al.
Published: (2023)

Tethered cord syndrome-role of early surgery
by: Deepti Vepakomma, et al.
Published: (2019)

Coumarin Triazoles as Potential Antimicrobial Agents
by: Siddappa A. Patil, et al.
Published: (2023)

Development of novel isatin-nicotinohydrazide hybrids with potent activity against susceptible/resistant Mycobacterium tuberculosis and bronchitis causing-bacteria
by: Zainab M. Elsayed, et al.
Published: (2021)

Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies
by: Mohammed S. Taghour, et al.
Published: (2022)

The inhibition of adenylate kinase by 2,4-thiazolidinedione evaluated by protein-ligand docking
by: Mihaela Ileana Ionescu
Published: (2017)

Mechanistic Insights into Binding of Ligands with Thiazolidinedione Warhead to Human Histone Deacetylase 4
by: Markus Schweipert, et al.
Published: (2021)

Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors
by: Simone Giovannuzzi, et al.
Published: (2023)

Strawberry and Ginger Silver Nanoparticles as Potential Inhibitors for SARS-CoV-2 Assisted by In Silico Modeling and Metabolic Profiling
by: Mohammad M. Al-Sanea, et al.
Published: (2021)

New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies
by: Hazem Elkady, et al.
Published: (2022)

The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors
by: Aleksandrs Pustenko, et al.
Published: (2020)