Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARγ

• Main Authors: Guoxi Li (Author), Libin Zhou (Author), Ying Zhu (Author), Conghui Wang (Author), Sha Sha (Author), Xunde Xian (Author), Yong Ji (Author), George Liu (Author), Ling Chen (Author)
• Format: Book
• Published: The Company of Biologists, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The seipin gene (BSCL2) was originally identified in humans as a loss-of-function gene associated with congenital generalized lipodystrophy type 2 (CGL2). Neuronal seipin-knockout (seipin-nKO) mice display a depression-like phenotype with a reduced level of hippocampal peroxisome proliferator-activa...