Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARγ

• Auteurs principaux: Guoxi Li (Auteur), Libin Zhou (Auteur), Ying Zhu (Auteur), Conghui Wang (Auteur), Sha Sha (Auteur), Xunde Xian (Auteur), Yong Ji (Auteur), George Liu (Auteur), Ling Chen (Auteur)
• Format: Livre
• Publié: The Company of Biologists, 2015-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The seipin gene (BSCL2) was originally identified in humans as a loss-of-function gene associated with congenital generalized lipodystrophy type 2 (CGL2). Neuronal seipin-knockout (seipin-nKO) mice display a depression-like phenotype with a reduced level of hippocampal peroxisome proliferator-activa...