Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARγ

• Egile Nagusiak: Guoxi Li (Egilea), Libin Zhou (Egilea), Ying Zhu (Egilea), Conghui Wang (Egilea), Sha Sha (Egilea), Xunde Xian (Egilea), Yong Ji (Egilea), George Liu (Egilea), Ling Chen (Egilea)
• Formatua: Liburua
• Argitaratua: The Company of Biologists, 2015-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The seipin gene (BSCL2) was originally identified in humans as a loss-of-function gene associated with congenital generalized lipodystrophy type 2 (CGL2). Neuronal seipin-knockout (seipin-nKO) mice display a depression-like phenotype with a reduced level of hippocampal peroxisome proliferator-activa...