Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARγ

• Autori principali: Guoxi Li (Autore), Libin Zhou (Autore), Ying Zhu (Autore), Conghui Wang (Autore), Sha Sha (Autore), Xunde Xian (Autore), Yong Ji (Autore), George Liu (Autore), Ling Chen (Autore)
• Natura: Libro
• Pubblicazione: The Company of Biologists, 2015-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The seipin gene (BSCL2) was originally identified in humans as a loss-of-function gene associated with congenital generalized lipodystrophy type 2 (CGL2). Neuronal seipin-knockout (seipin-nKO) mice display a depression-like phenotype with a reduced level of hippocampal peroxisome proliferator-activa...