Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis

• Main Authors: Shiyun Pu (Author), Yanping Li (Author), Qinhui Liu (Author), Xu Zhang (Author), Lei Chen (Author), Rui Li (Author), Jinhang Zhang (Author), Tong Wu (Author), Qin Tang (Author), Xuping Yang (Author), Zijing Zhang (Author), Ya Huang (Author), Jiangying Kuang (Author), Hong Li (Author), Min Zou (Author), Wei Jiang (Author), Jinhan He (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Purpose: Activation of hepatic stellate cells (HSC) is a central driver of liver fibrosis. 5-lipoxygenase (5-LO) is the key enzyme that catalyzes arachidonic acid into leukotrienes. In this study, we examined the role of 5-LO in HSC activation and liver fibrosis.Main Methods: Culture...