Neuroprotective effects of DAHP and Triptolide in Focal Cerebral Ischemia via Apoptosis Inhibition and PI3K/Akt/mTOR pathway Activation

• Main Authors: Weiyun eLi (Author), Yang eYang (Author), Zhiying eHu (Author), Shucai eLing (Author), Marong eFang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triptolide (TP), one of the major active components of the traditional Chinese herb Tripterygium wilfordii Hook F, and 2, 4-diamino-6-hydroxypyrimidine (DAHP), an inhibitor of tetrahydrobiopterin (BH4) synthesis, have been reported to have potent anti-inflammatory and immunosuppressive properties. Ho...