Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells.

• Main Authors: Pamela Cribb (Author), Virginia Perdomo (Author), Victoria L Alonso (Author), Romina Manarin (Author), Jorge Barrios-Payán (Author), Brenda Marquina-Castillo (Author), Luis Tavernelli (Author), Rogelio Hernández-Pando (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:High Mobility Group B (HMGB) proteins are nuclear architectural factors involved in chromatin remodeling and important nuclear events. HMGBs also play key roles outside the cell acting as alarmins or Damage-associated Molecular Patterns (DAMPs). In response to a danger signal these protei...