Antitumor Macrophage Response to Bacillus pumilus Ribonuclease (Binase)

• Main Authors: Anna Makeeva (Author), Hector A. Cabrera-Fuentes (Author), Julian Rodriguez-Montesinos (Author), Pavel Zelenikhin (Author), Alexander Nesmelov (Author), Klaus T. Preissner (Author), Olga N. Ilinskaya (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Extracellular bacterial ribonucleases such as binase from Bacillus pumilus possess cytotoxic activity against tumor cells with a potential for clinical application. Moreover, they may induce activation of tumor-derived macrophages either into the M1-phenotype with well-documented functions in the re...