Regulatory variants in a novel distal enhancer regulate the expression of CYP3A4 and CYP3A5

• Main Authors: Joseph M. Collins (Author), Adaeze C. Nworu (Author), Somayya J. Mohammad (Author), Liang Li (Author), Chengcheng Li (Author), Chuanjiang Li (Author), Ethan Schwendeman (Author), Mattew Cefalu (Author), Mahmoud Abdel‐Rasoul (Author), Jessie W. Sun (Author), Sakima A. Smith (Author), Danxin Wang (Author)
• Format: Book
• Published: Wiley, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The cytochrome P450 3As (CYP3As) are abundantly expressed in the liver and metabolize many commonly prescribed medications. Their expression is highly variable between individuals with little known genetic cause. Despite extensive investigation, cis‐acting genetic elements that control the...