Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations

• Main Authors: Rani Sasidharan (Author), Bo Hyun Eom (Author), Jeong Hyun Heo (Author), Jong Eun Park (Author), Mohamed A. Abdelgawad (Author), Arafa Musa (Author), Nicola Gambacorta (Author), Orazio Nicolotti (Author), Sreedharannair Leelabaiamma Manju (Author), Bijo Mathew (Author), Hoon Kim (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nine compounds (MO1-MO9) containing the morpholine moiety were assessed for their inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). Most of the compounds potently inhibited MAO-B; MO1 most potently inhibited with an IC50 value of 0.030 µM, followed by MO7 (0.25...