Anti-PEG IgM Response against PEGylated Liposomes in Mice and Rats

• Main Authors: Hiroshi Kiwada (Author), Tatsuhiro Ishida (Author), Yumi Uehara (Author), Yuki Hashiguchi (Author), Ami Imoto (Author), Taro Shimizu (Author), Masako Ichihara (Author)
• Format: Book
• Published: MDPI AG, 2010-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have reported that PEGylated liposomes lose their long-circulating properties when they are administered repeatedly at certain intervals to the same animal. This unexpected phenomenon is referred to as the accelerated blood clearance (ABC) phenomenon. We recently showed that the ABC phenomenon is...