Model based assessment of food and acid reducing agent effects on oral absorption of mezigdomide (CC‐92480), a novel cereblon E3 ligase modulator

Abstract Mezigdomide is a novel cereblon E3 ligase modulator (CELMoD) agent with enhanced autonomous cell‐killing activity in multiple myeloma (MM) cells, and promising immunomodulatory and antitumor activity in patients with MM. We developed a population pharmacokinetics (PKs) model for mezigdomide...

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Bibliographic Details
Main Authors: Fan Wu (Author), Liangang Liu (Author), Allison Gaudy (Author), Xiaomin Wang (Author), Leon Carayannopoulos (Author), Michael Pourdehnad (Author), Manisha Lamba (Author)
Format: Book
Published: Wiley, 2023-10-01T00:00:00Z.
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