ROS-Mediated NLRP3 Inflammasome Activity Is Essential for Burn-Induced Acute Lung Injury

• Main Authors: Shichao Han (Author), Weixia Cai (Author), Xuekang Yang (Author), Yanhui Jia (Author), Zhao Zheng (Author), Hongtao Wang (Author), Jun Li (Author), Yan Li (Author), Jianxin Gao (Author), Lei Fan (Author), Dahai Hu (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The NLRP3 inflammasome is necessary for initiating acute sterile inflammation. However, its role in the pathogenesis of burn-induced acute lung injury (ALI) is unknown. This study aimed to determine the role of the NLRP3 inflammasome and the signaling pathways involved in burn-induced ALI. We observ...