Possible effects of inhibition of IKr and IKs on field-potential waveforms in the human iPS cell-derived cardiomyocytes sheet

• Main Authors: Junko Matsuo (Author), Yuji Nakamura (Author), Hiroko Izumi-Nakaseko (Author), Kentaro Ando (Author), Yuko Sekino (Author), Atsushi Sugiyama (Author)
• Format: Book
• Published: Elsevier, 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In order to investigate how IKr and IKs inhibitions affect waveforms of the field potential in the human iPS cell-derived cardiomyocytes sheet, we analyzed the effects of E-4031 and chromanol 293B on the maximum upslope and peak amplitude of its second wave (n = 7 for each drug). E-4031 in 10-100 nM...