Disruption of piRNA machinery by deletion of ASZ1/GASZ results in the expression of aberrant chimeric transcripts in gonocytes

• Main Authors: Shinya IKEDA (Author), Koki TANAKA (Author), Reiko OHTANI (Author), Akifumi KANDA (Author), Yusuke SOTOMARU (Author), Tomohiro KONO (Author), Yayoi OBATA (Author)
• Format: Book
• Published: The Society for Reproduction and Development, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the male germline, the machinery to repress retrotransposons that threaten genomic integrity via the piRNA pathway is established in gonocytes. It has been reported that disruption of the piRNA pathway leads to activation of retrotransposons and arrests spermatogenesis before it enters the second...