Induction of Steatohepatitis (NASH) with Insulin Resistance in Wild-type B6 Mice by a Western-type Diet Containing Soybean Oil and Cholesterol

• Main Authors: Janin Henkel (Author), Charles Dominic Coleman (Author), Anne Schraplau (Author), Korinna Jöhrens (Author), Daniela Weber (Author), José Pedro Castro (Author), Martin Hugo (Author), Tim Julius Schulz (Author), Stephanie Krämer (Author), Annette Schürmann (Author), Gerhard Paul Püschel (Author)
• Format: Book
• Published: BMC, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are hepatic manifestations of the metabolic syndrome. Many currently used animal models of NAFLD/NASH lack clinical features of either NASH or metabolic syndrome such as hepatic inflammation and fibrosis (e.g.,...