Applicability of generic assays based on liquid chromatography-electrospray mass spectrometry to study in vitro metabolism of 55 structurally diverse compounds

• Główni autorzy: Timo Rousu (Autor), Juho Hokkanen (Autor), Olavi R Pelkonen (Autor), Ari Tolonen (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2010-08-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Liquid chromatography-mass spectrometry (LC/MS) with generic gradient elution for a large number of chemically different compounds is a common approach in drug development, used to acquire a large amount of data in a short time frame for drug candidates. The analysis with non-optimised parameters ho...