Optimization of Spray Drying Process Parameters for the Preparation of Inhalable Mannitol-Based Microparticles Using a Box-Behnken Experimental Design

• Main Authors: Jakub Karas (Author), Sylvie Pavloková (Author), Hana Hořavová (Author), Jan Gajdziok (Author)
• Format: Bog
• Udgivet: MDPI AG, 2023-02-01T00:00:00Z.
• Fag: article
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Inhalation is used for local therapy of the lungs and as an alternative route for systemic drug delivery. Modern powder inhalation systems try to target the required site of action/absorption in the respiratory tract. Large porous particles (LPPs) with a size >5 μm and a low mass density (usually...