CCN2 Activates RIPK3, NLRP3 Inflammasome, and NRF2/Oxidative Pathways Linked to Kidney Inflammation

• Main Authors: Sandra Rayego-Mateos (Author), Laura Marquez-Exposito (Author), Pamela Basantes (Author), Lucia Tejedor-Santamaria (Author), Ana B. Sanz (Author), Tri Q. Nguyen (Author), Roel Goldschmeding (Author), Alberto Ortiz (Author), Marta Ruiz-Ortega (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammation is a key characteristic of both acute and chronic kidney diseases. Preclinical data suggest the involvement of the NLRP3/Inflammasome, receptor-interacting protein kinase-3 (RIPK3), and NRF2/oxidative pathways in the regulation of kidney inflammation. Cellular communication network fact...