Novel FFA1 (GPR40) agonists containing spirocyclic periphery: polar azine periphery as a driver of potency

A series of nine compounds based on 3-[4-(benzyloxy)phenyl]propanoic acid core containing a 1-oxa-9-azaspiro[5.5]undecane periphery was designed, synthesized and evaluated as free fatty acid 1 (FFA1 or GPR40) agonists. The spirocyclic appendages included in these compounds were inspired by LY2881835...

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Main Authors: Mikhail Krasavin (Author), Alexey Lukin (Author), Daria Bagnyukova (Author), Nikolay Zhurilo (Author), Ihor Zahanich (Author), Sergey Zozulya (Author)
Formato: Livro
Publicado em: Taylor & Francis Group, 2017-01-01T00:00:00Z.
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