HPMA-Based Copolymers Carrying STAT3 Inhibitor Cucurbitacin-D as Stimulus-Sensitive Nanomedicines for Oncotherapy

• Main Authors: Marina R. Tavares (Author), Klára Hrabánková (Author), Rafał Konefał (Author), Martin Kaňa (Author), Blanka Říhová (Author), Tomáš Etrych (Author), Milada Šírová (Author), Petr Chytil (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The study describes the synthesis, physicochemical properties, and biological evaluation of polymer therapeutics based on <i>N</i>-(2-hydroxypropyl)methacrylamide (HPMA) copolymers intended for a tumor-targeted immuno-oncotherapy. Water-soluble linear and cholesterol-containing HPMA prec...