Gene Expression and Protein Abundance of Hepatic Drug Metabolizing Enzymes in Liver Pathology

• Main Authors: Marek Drozdzik (Author), Joanna Lapczuk-Romanska (Author), Christoph Wenzel (Author), Sylwia Szelag-Pieniek (Author), Mariola Post (Author), Łukasz Skalski (Author), Mateusz Kurzawski (Author), Stefan Oswald (Author)
• 格式: 图书
• 出版: MDPI AG, 2021-08-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Hepatic drug metabolizing enzymes (DMEs) markedly affect drug pharmacokinetics. Because liver diseases may alter enzymatic function and in turn drug handling and clinical efficacy, we investigated DMEs expression in dependence on liver pathology and liver failure state. In 5 liver pathologies (hepat...