Fisetin Inhibits NLRP3 Inflammasome by Suppressing TLR4/MD2-Mediated Mitochondrial ROS Production

• Main Authors: Ilandarage Menu Neelaka Molagoda (Author), Athapaththu Mudiyanselage Gihan Kavinda Athapaththu (Author), Yung Hyun Choi (Author), Cheol Park (Author), Cheng-Yung Jin (Author), Chang-Hee Kang (Author), Mi-Hwa Lee (Author), Gi-Young Kim (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fisetin has numerous therapeutic properties, such as anti-inflammatory, antioxidative, and anticancer effects. However, the mechanism by which fisetin inhibits NLRP3 inflammasome remains unclear. In this study, we observed that fisetin bound to TLR4 and occluded the hydrophobic pocket of MD2, which...