Oral Administration of TrkB Agonist, 7, 8-Dihydroxyflavone Regenerates Hair Cells and Restores Function after Gentamicin-Induced Vestibular Injury in Guinea Pig

• Main Authors: Makoto Kinoshita (Author), Chisato Fujimoto (Author), Shinichi Iwasaki (Author), Kenji Kondo (Author), Tatsuya Yamasoba (Author)
• Format: Knjiga
• Izdano: MDPI AG, 2023-02-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

The causes of vestibular dysfunction include the loss of hair cells (HCs), synapses beneath the HCs, and nerve fibers. 7, 8-dihydroxyflavone (DHF) mimics the physiological functions of brain-derived neurotrophic factor. We investigated the effects of the orally-administered DHF in the guinea pig cri...