CD154 Induces Interleukin-6 Secretion by Kidney Tubular Epithelial Cells under Hypoxic Conditions: Inhibition by Chloroquine

• Main Authors: Antoine Dewitte (Author), Julien Villeneuve (Author), Sébastien Lepreux (Author), Marion Bouchecareilh (Author), Xavier Gauthereau (Author), Claire Rigothier (Author), Christian Combe (Author), Alexandre Ouattara (Author), Jean Ripoche (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammation is a major contributor to tubular epithelium injury in kidney disorders, and the involvement of blood platelets in driving inflammation is increasingly stressed. CD154, the ligand of CD40, is one of the mediators supporting platelet proinflammatory properties. Although hypoxia is an ess...