Epilepsy-Induced High Affinity Blockade of the Cardiac Sodium Current I_Na by Lamotrigine; A Potential for Acquired Arrythmias

• Auteurs principaux: Juan Antonio Contreras Vite (Auteur), Carlos Vega Valle (Auteur), Happi Biekeu Mbem (Auteur), Sarah-Maude Boivin (Auteur), Robert Dumaine (Auteur)
• Format: Livre
• Publié: MDPI AG, 2022-09-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Lamotrigine is widely prescribed to treat bipolar neurological disorder and epilepsy. It exerts its antiepileptic action by blocking voltage-gated sodium channels in neurons. Recently, the US Food and Drug Administration issued a warning on the use of Lamotrigine after observations of conduction ano...