Epilepsy-Induced High Affinity Blockade of the Cardiac Sodium Current I_Na by Lamotrigine; A Potential for Acquired Arrythmias

• Päätekijät: Juan Antonio Contreras Vite (Tekijä), Carlos Vega Valle (Tekijä), Happi Biekeu Mbem (Tekijä), Sarah-Maude Boivin (Tekijä), Robert Dumaine (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2022-09-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Lamotrigine is widely prescribed to treat bipolar neurological disorder and epilepsy. It exerts its antiepileptic action by blocking voltage-gated sodium channels in neurons. Recently, the US Food and Drug Administration issued a warning on the use of Lamotrigine after observations of conduction ano...