Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe

• Main Authors: Gaspard Kerner (Author), Anna-Lena Neehus (Author), Quentin Philippot (Author), Jonathan Bohlen (Author), Darawan Rinchai (Author), Nacim Kerrouche (Author), Anne Puel (Author), Shen-Ying Zhang (Author), Stéphanie Boisson-Dupuis (Author), Laurent Abel (Author), Jean-Laurent Casanova (Author), Etienne Patin (Author), Guillaume Laval (Author), Lluis Quintana-Murci (Author)
• Format: Book
• Published: Elsevier, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Ancient genomics can directly detect human genetic adaptation to environmental cues. However, it remains unclear how pathogens have exerted selective pressures on human genome diversity across different epochs and affected present-day inflammatory disease risk. Here, we use an ancestry-awar...