Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe

• Автори: Gaspard Kerner (Автор), Anna-Lena Neehus (Автор), Quentin Philippot (Автор), Jonathan Bohlen (Автор), Darawan Rinchai (Автор), Nacim Kerrouche (Автор), Anne Puel (Автор), Shen-Ying Zhang (Автор), Stéphanie Boisson-Dupuis (Автор), Laurent Abel (Автор), Jean-Laurent Casanova (Автор), Etienne Patin (Автор), Guillaume Laval (Автор), Lluis Quintana-Murci (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2023-02-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Summary: Ancient genomics can directly detect human genetic adaptation to environmental cues. However, it remains unclear how pathogens have exerted selective pressures on human genome diversity across different epochs and affected present-day inflammatory disease risk. Here, we use an ancestry-awar...