Multi‐model averaging improves the performance of model‐guided infliximab dosing in patients with inflammatory bowel diseases

• Main Authors: Wannee Kantasiripitak (Author), An Outtier (Author), Sebastian G. Wicha (Author), Alexander Kensert (Author), Zhigang Wang (Author), João Sabino (Author), Séverine Vermeire (Author), Debby Thomas (Author), Marc Ferrante (Author), Erwin Dreesen (Author)
• Format: Book
• Published: Wiley, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Infliximab dosage de‐escalation without prior knowledge of drug concentrations may put patients at risk for underexposure and trigger the loss of response. A single‐model approach for model‐informed precision dosing during infliximab maintenance therapy has proven its clinical benefit in pa...