Microsomal glutathione transferase 1 controls metastasis and therapeutic response in melanoma

• Main Authors: Jie Zhang (Author), Zhi-wei Ye (Author), Paramita Chakraborty (Author), Zhenwu Luo (Author), John Culpepper (Author), Muhammad Aslam (Author), Leilei Zhang (Author), Katarina Johansson (Author), Jesper Z. Haeggström (Author), Jianqiang Xu (Author), Magnus Olsson (Author), Danyelle M. Townsend (Author), Shikhar Mehrotra (Author), Ralf Morgenstern (Author), Kenneth D. Tew (Author)
• Format: Book
• Published: Elsevier, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

While recent targeted and immunotherapies in malignant melanoma are encouraging, most patients acquire resistance, implicating a need to identify additional drug targets to improve outcomes. Recently, attention has been given to pathways that regulate redox homeostasis, especially the lipid peroxida...