Melatonin Alleviates LPS-Induced Pyroptotic Cell Death in Human Stem Cell-Derived Cardiomyocytes by Activating Autophagy

• Main Authors: Ya Qiu (Author), Yan Ma (Author), Min Jiang (Author), Sulei Li (Author), Jibin Zhang (Author), Haixu Chen (Author), Mengqi Xu (Author), Shan Gao (Author), Lei Tian (Author), Bo Tao (Author), Yabin Wang (Author), Dong Han (Author), Feng Cao (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endotoxemia in sepsis remains a problem due to a lack of effective strategies. Our previous studies have demonstrated that melatonin (Mel) protects against ischemic heart injury and arteriosclerosis. However, its role in endotoxemia-exposed cardiomyocytes remains poorly understood. This study explor...