Olmesartan Prevents Microalbuminuria in db/db Diabetic Mice Through Inhibition of Angiotensin II/p38/SIRT1-Induced Podocyte Apoptosis

• Main Authors: Junhui Gu (Author), Ming Yang (Author), Na Qi (Author), Shuqin Mei (Author), Jiejian Chen (Author), Shuwei Song (Author), Ying Jing (Author), Meihan Chen (Author), Liangliang He (Author), Lijun Sun (Author), Huimin Hu (Author), Lin Li (Author), Rudolf P. Wüthrich (Author), Ming Wu (Author), Changlin Mei (Author)
• Format: Book
• Published: Karger Publishers, 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Blockage of the renin-angiotensin II system (RAS) prevents or delays albuminuria in diabetic patients. The aim of this study was to investigate the inhibitory mechanism of the angiotensin receptor blocker olmesartan on albuminuria in a murine model of diabetic nephropathy. Methods:...