Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids

• Główni autorzy: Alba Vidal-Torres (Autor), Begoña Fernández-Pastor (Autor), Mónica García (Autor), Eva Ayet (Autor), Anna Cabot (Autor), Javier Burgueño (Autor), Xavier Monroy (Autor), Bertrand Aubel (Autor), Xavier Codony (Autor), Luz Romero (Autor), Rosalía Pascual (Autor), Maria Teresa Serafini (Autor), Gregorio Encina (Autor), Carmen Almansa (Autor), Daniel Zamanillo (Autor), Manuel Merlos (Autor), José Miguel Vela (Autor)
• Format: Książka
• Wydane: Elsevier, 2023-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Opioids are the most effective painkillers, but their benefit-risk balance often hinder their therapeutic use. WLB-73502 is a dual, bispecific compound that binds sigma-1 (S1R) and mu-opioid (MOR) receptors. WLB-73502 is an antagonist at the S1R. It behaved as a partial MOR agonist at the G-protein...