Polymeric Particle BAM15 Targeting Macrophages Attenuates the Severity of LPS-Induced Sepsis: A Proof of Concept for Specific Immune Cell-Targeted Therapy

• Main Authors: Kanyarat Udompornpitak (Author), Thansita Bhunyakarnjanarat (Author), Wilasinee Saisorn (Author), Chonnavee Manipuntee (Author), Kittawat Plengplang (Author), Samarch Sittichaitaweekul (Author), Panisa Jenphatanapong (Author), Suwasin Udomkarnjananun (Author), Warerat Kaewduangduen (Author), Kasirapat Ariya-anandech (Author), Amanee Samaeng (Author), Numpon Insin (Author), Patcharee Ritprajak (Author), Asada Leelahavanichkul (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Macrophage polarization requires different energy sources and metabolic processes. Therefore, cell energy interference to alter macrophage functions has been proposed as a treatment for severe inflammatory diseases, including sepsis. In this study, targeting cell energy using BAM15 (a mitochondrial...