Fluoxetine prevents Aβ1-42-induced toxicity via a paracrine signaling mediated by Transforming-Growth-Factor-β1

• Main Authors: Filippo Caraci (Author), Fabio Tascedda (Author), Sara Merlo (Author), Cristina Benatti (Author), Simona Federica Spampinato (Author), Antonio Munafò (Author), Gian Marco Leggio (Author), Ferdinando Nicoletti (Author), Nicoletta Brunello (Author), Filippo Drago (Author), Maria Angela Sortino (Author), Agata Copani (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Selective reuptake inhibitors (SSRIs), such as fluoxetine and sertraline, increase circulating Transforming-Growth-Factor-β1 (TGF-ß1) levels in depressed patients,and are currently studied for their neuroprotective properties in Alzheimer's disease (AD). TGF-β1 is an anti-inflammatory cytokine...